Neuropeptide Deep Wrinkle Serum

A Filler on the Go

I consider Deep Wrinkle Serum to be a kind of a skincare swiss army knife. It hydrates, “fills”, plumps and calms almost any skin type instantly. I tend to be on the normal/oily side, with some dryness in certain areas, like the area around my eyes and in the smile creases and this is my favorite way to hydrate those targeted areas. While it may be no news that adequately hydrated skin doesn’t show imperfections like fine lines and wrinkles as obviously, I have to say that the results of Deep Wrinkle Serum are well beyond just basic hydration. It’s actually kind of magical to watch. Deep Wrinkle Serum has almost a water-like fluid texture and is packed with a potent cocktail of Neuropeptides and phospholipids, which, together relax the lines (almost like the stiffness of the line is gone) and go to work repairing the tiny micro-tears that make up the wrinkle, giving a significant ‘plumping effect’. Thanks to the sodium hyaluronic acid base, it actually binds moisture to your skin throughout the day, ensuring that makeup goes on more evenly and no cake-y patches occur.

Remember, you will see instant results, but only with continued use will you see skin transforming benefits. Lastly, I love that it’s a clean formulation, free of synthetic waxes, actual fillers, optical diffusers, fragrances or parabens in this serum.

My Deep Wrinkle Serum Tips:

  • Add a drop or two under the eye area before you apply your eye treatment.
  • Massage the drops into any visible line- you’ll see a difference.
  • Add a drop to the lip area before applying a lip treatment. Lips appear fuller and more hydrated.
  • Keep it in your purse and dap a drop on here or there throughout the day.

What are your Deep Wrinkle Serum tips?  

Dr. Nicholas Perricone

Beauty Rx: Skin Fixes

Here are our 3 favorite pieces of skincare wisdom from Dr. Perricone on Refinery29‘s article,  “Beauty Rx: Foods to Cure Your Beauty Woes.”

“If women understood that eating a simple can of sardines or salmon would give their hair and skin an unrivaled radiance, softness, and suppleness — like nothing else in this world — these foods would fly off the supermarket shelves. You would see a stampede toward the fish aisle.”

“Healthy fats are key to successful weight loss. Good fats are those found in salmon, sardines, anchovies, extra virgin olive oil, nuts, seeds, and avocado. These ‘good’ fats will help us absorb nutrients from our vegetables and fruits, and are key to weight loss because we also need dietary fat to burn fat.”

“Dry skin is actually a manifestation of chronic subclinical (invisible to the eye) inflammation. Make sure that you have adequate intake of healthy fats, such as those found in fish, fish oil, and extra virgin olive oil. While topicals can do wonders [for dry skin] it is critically important to not forget the dietary component, which can both cause and worsen all of these conditions.”

What is your favorite piece of skincare wisdom?

spring ready skin

3 Scary Skin Changes

“We do not have to age the way our parents did.” – Dr. Nicholas Perricone

It’s true- thanks in part to the technological advancements in skin care and increased knowledge about skin’s underlying structure. Here are 3 potentially worrisome changes that skin undergoes as we age and some product fixes that can help.

1. Skin Change: Increased dryness. After age 30, skin’s oil glands reduce their production significantly, and the loss continues as we age.

Fix: Upgrade your moisturizer to a more nourishing, antioxidant based formula. Tip: Don’t be fooled by “rich” feeling moisturizers containing mineral-oil. This is a cheap filler ingredient that can actually act as a barrier to allowing the nutrients into the skin.

2. Skin Change:  Age spots. Visible hyperpigmentation caused by sun damage. Melanocytes actually “burn out” at around the 30’s or 40’s, which reduces the skin’s natural defense mechanism to fight sun damage, often resulting in uneven pigmentation.

Fix: Seek out a corrective treatment that works to “erase” sun spots and uneven pigmentation. Tip: Opt for a hydroquinone (bleach)-free formulation for optimum skin health.

Product pick: Vitamin C Ester 15. Fast acting and safe product to visibly break up and erase hyperpigmenation. A must have for anyone with sun damage.

3. Skin Change: Thinning. Thinning skin caused by the dermis and the skin’s fat layer thinning (around age 40 typically) and picking up speed around age 50 for most women. This results in the visible sagging of the skin and the loss of that plump, supple look. Even worse? This loss of the fat layer actually makes skin even more susceptible to damage and abrasion.

Fix: Incorporate products that enhance collagen and elastin production to help “redensify” skin’s appearance. Retinol and Vitamin C Ester are ingredients to look for.

Product picks: HP Amine Face Lift formulated with Vitamin C Ester and pycnogenol, a skin strengthener. HP Evening Evening Repair formulated with a therapeutic dose of retinol to encourage cell turn over and repair.

What changes have you noticed in your skin as you’ve aged?

Sugar and Skin Conditions

Sugar in all of its forms (corn syrup, cane sugar, high fructose corn syrup, etc.) is extremely damaging to the skin–and in fact to all organ systems.

Sugar and foods that rapidly convert to sugar when eaten cause sudden spikes in blood sugar levels, resulting in the release of insulin into the blood stream, that then cause us to store, rather than burn fat. However, that is not the only negative byproduct.

As these sugars and starches are eaten, they cause a burst of inflammation throughout the body.  The sugar molecule can also permanently attach to protein, such as the collagen present in our skin and other parts of the body.  This process is known as glycation.

At the point of attachment, there is a small mechanism creating inflammation, which then becomes a source of inflammation in its own right.  This inflammation produces enzymes that break down collagen, resulting in wrinkled, sagging skin.  In addition to inflammation, glycation also causes cross-linking in our collagen, making it stiff and inflexible where it was once soft and supple.

But it is not just the skin we have to worry about.  These “sugar-bonds” can occur throughout the body as we age.  The sugar molecule attaches itself to our collagen as well as our arteries, veins, bones, ligaments, even our brains, resulting in the breakdown of organ systems and the deterioration of the body. Glycation creates “free radical” factories known as advanced glycation end products (AGEs), which also increase cellular inflammation.

Sugar consumption can also affect acne.  When our blood sugar and insulin levels rise, whether from a poor diet or from stress, we experience a serious increase in inflammatory chemicals at a cellular level. This causes inflammatory diseases such as acne to worsen dramatically.  Cortisol and other adrenal steroids can act as androgens (male hormones) and stimulate the sebaceous (oil) glands resulting in a flare-up of acne.

If you are concerned about your health, and not accelerating the aging process, it is best to avoid all forms of refined sugar as well as chemical artificial sweeteners.  There are natural sugars found in fruits and vegetables that should be our only source of sugar.  These foods are high in anti-inflammatory anti-oxidants, help stabilize blood sugar, and nutrients that promote beautiful skin and a healthy body.

Why Customers Love Advanced Face Firming Activator

Advanced Face Firming Activator has been one of our top selling products for years.  It is highly effective in correcting imperfections, shrinking pores, and reducing redness and the appearance of fine lines and wrinkles.

But don’t just take our word for it! Read what customers are saying:

“I have been using this product for a few months and I just love how it makes my skin feel and look. Great value for the price too. An all around great idea and deal.”

-Anu from Washington DC

“Wow, this is one of my fave beauty products. And I happen to be a product-junkie. Just try it once to feel the difference.”

- Jman from California

“I use this product every day and I think its amazing for all ages. I’ve noticed a difference in the brightness of my eyes.”

- Yasmeen from New York

“I have been using Dr. Perricone products for several years now, and Advanced Face Firming Activator is part of my daily skin care routine. My 62 year old skin looks better than it ever has. I am happy to report that the fine lines around my eyes are nearly gone.”

- Bonnie from South Carolina

If you love Advanced Face Firming Activator or one of our other highly effective anti-aging products, why not let others know how it works for you? Write a review on our website today on any of our product pages!

The 10 Sins of Skin Aging

  1. Pro-Inflammatory foods (sugar and starches)
    Foods can be pro-inflammatory or anti-inflammatory. Avoid pro-inflammatory foods—these will promote wrinkles, a host of diseases, accelerate aging and cause the storage of body fat.  Eating pro-inflammatory foods such as sugary and starchy foods shows up on the skin as a loss of radiance, dark circles under the eyes, the loss of tone, puffiness, an increase in fine lines and wrinkles, the loss of facial contours and increased pore size.  These foods can also exacerbate acne, which is a systemic, inflammatory disease.   I am not exaggerating when I say that sugar can rob you of your youth, health, and beauty.
  2. Excessive exposure to the sun.
    Although we have all heard it a million times, excessive sun exposure will accelerate skin aging and cause skin cancer. We need to get some sun in order to absorb Vitamin D and keep our bones strong and healthy.  However, baking out in the hot sun at the beach or by the pool is very destructive to your skin, as well as to your immune system.  Excess sun exposure will cause photoaging, resulting in the following:

    Loss of skin elasticity
    Thinner, more translucent-looking skin
    Wrinkles
    Dry, rough, leathery skin
    Broken capillaries on the face
    Freckles,
    Liver spots on the face, back of hands, arms, chest and upper back
    Spots or blemishes on the lower legs and arms
    Skin Cancer
  3. Stress
    Of all the destructive, pro-inflammatory and pro-aging forces I have observed as a physician, nothing compares with the negative effects of stress. Stress causes certain hormonal changes in your body, which rapidly alters the function of the cells in your vital organs. Not surprisingly, these effects are reflected in the appearance of your skin.
     
    Stress causes the release of the hormone cortisol.  When we have large amounts of cortisol circulating in our blood streams for extended periods of time, it is extremely toxic. Our brain cells, or neurons, are extremely sensitive to the effects of cortisol. When it is circulating at a high level, cortisol causes brain cells to die. Excess cortisol can destroy your immune system, shrink other vital organs, decrease your muscle mass, and cause thinning of the skin, accelerating skin aging and wrinkling and making blood vessels under skin more prominent.
  4. Smoking Cigarettes and/or exposure to second hand smoke
    Cigarette smoke is highly damaging and aging to skin. When we inhale just one puff of a cigarette, over a trillion free radicals are produced in our lungs, which then trigger an inflammatory response that circulates throughout our body.  When we inhale tobacco smoke, the result is activation of white blood cells which line our arteries, causing an inflammatory response, predisposing us to heart disease. 
     

    In addition, there is a tremendous inflammatory response in all organs of the body —including the skin. Cigarette smoking depletes the skin of oxygen and vital nutrients including Vitamin C, critical in keeping skin youthful, moist and plumped up. Tobacco also acts as a vasoconstrictor, which means that it causes constriction of blood vessels. This reduces local blood flow to an area, and temporarily raises blood pressure.  When the blood flow is reduced to the skin it results in a gray, pallid, lifeless and unhealthy looking complexion. Smoking also causes dry, leathery looking skin, premature deep lines, wrinkles and loss of radiance.

  5. Excess Alcohol
    People generally think that alcohol is bad for the skin just because it dehydrates the body.  They incorrectly assume that increasing our water intake will counteract the problem.  Unfortunately, alcohol creates inflammation throughout the body including the skin, resulting in effects that far outlast dehydration.  The metabolites of alcohol are molecules known as aldehydes.  Aldehydes are destructive in that they cause damage to the cell plasma membrane, as well as other parts of the interior of the cell.
     

    Alcohol causes small blood vessels in the skin to widen, allowing more blood to flow close to the skin’s surface. This produces a flushed skin color and a feeling of warmth which can lead to broken capillaries on the face. The alcohol-induced dehydration also makes the skin more prone to fine lines and wrinkles.

    Dullness, enlarged pores, discoloration, sagging and lack of resilience are some of the short and longer term effects. Because alcohol alters blood flow to the skin, it will give you an unhealthy appearance that can last for days. An occasional glass of red wine can confer some health benefits for a number of reasons.  But as with everything from eating to exercise, moderation is the key.  Too much alcohol is highly destructive.

  6. Lack of sleep
    A good night’s sleep will ensure that you awake refreshed, looking radiant and youthful. Adequate sleep is vital to avoid eye area puffiness and maintain vibrant skin.  When we look at the hormone parameters during sleep, we find that sleep turns down the negative effects of cortisol and the “bad” neurotransmitters, like epinephrine and norepinephrine that can be elevated during stress. Growth hormone is released during sleep—and growth hormone is the youth hormone. The hormone melatonin is also released, which has a positive effect on the immune system and the skin. It is during sleep that we rebuild energy reserves and regenerate the body as our cells undergo a process of repair.  Studies also show that inadequate sleep leads to unwanted weight gain and a craving for fat laden and carbohydrate-heavy foods.
     

    People who exercise regularly enjoy improved sleep quality. They fall asleep more quickly, sleep more deeply, awaken less often, and sleep longer.

  7. Lack of Exercise
    There are mountains of studies proving that exercise can take off pounds, reduce incidence of heart disease, lower blood pressure, improve mood, solve sleep problems, and even cut risks of certain cancers.  Exercise will also ensure that you have beautiful skin.  Studies have indicated that exercise benefits the skin in much the same way it improves bone and muscle quality.  Without regular activity, bones become fragile and muscles atrophy.  When the skin of those who exercise regularly is examined under a microscope, the impact of their high fitness levels is clearly apparent.  The clear skin is thicker and has more and healthier collagen, the fibers that give the skin its strength and flexibility.  Exercise increases circulation and gives the skin a healthy and radiant glow.  As long as we use moderation and don’t overdo it, exercise of almost any kind has a powerful, positive, and anti-inflammatory effect on all our cells.
  8. Not eating enough protein
    This ongoing lack of protein is first notable in the face, as the features become soft looking.  The sharp definition, contoured cheekbones and that great jaw line all becomes blurred.  When the supply of protein is depleted, the body is then forced to feed upon itself.  This causes both tissue and muscle to breakdown. Protein cannot be stored in the body.  Because it is essential for cellular repair, the days that we don’t eat enough protein are the days that we are accelerating aging.
  9. Going fat free
    Healthy fats, especially omega 3 fatty acids and monounsaturated fat, have powerful anti-inflammatory effects improving skin’s moistness, texture, suppleness and smoothness.  We need good fats, such as those found in salmon, sardines and other cold water fish, extra virgin olive oil, nuts, seeds, avocado and açai (a Brazilian berry whose fatty acid ratio resembles that of olive oil).  These “good” fats will help us absorb nutrients from our vegetables and fruits, keep our cells supple, our skin glowing and wrinkle-free, our brains sharp and our mood upbeat.  We also need dietary fat to burn fat.
  10. Not drinking enough water
    Remember these key facts:  Water is important—If you do not drink water, your organs and cells cannot function.  You don’t have to overdo it—but if you don’t drink water, you cannot metabolize fat, nor can you flush wastes out of the cells.

    A dehydrated body provokes the development of aging, inflammatory compounds.  Water has great anti-inflammatory properties and will help you skin to be radiant, soft and supple—the key difference between a grape and raisin is water.

Try Perricone Cold Plasma to reduce the 10 signs of aging.

Barbecue Your Way to Beautiful Skin

It’s summertime, and the grilling is easy.

Once of the joys of summertime is the barbecue.  Nothing tastes better than food cooked outdoors over an open fire.  But cooking muscle meats and other protein foods at high heats can create carcinogenic chemicals called heterocyclic amines (HCAs).  In addition, Advanced Glycation End Products (AGEs) are also created.  The more AGEs we have, the more oxidative stress in our bodies, accelerating aging and disease risk in all organ systems, including skin.  In fact, AGEs play a key role in both healthy aging and preventing wrinkles and deeply lined, sagging skin.

We can still barbecue and reduce our risk of creating toxins if we follow a few simple rules.

1.    Choose lean meat, ideally from grass fed cattle or lamb, fish and free-range poultry; trim any excess fat from meat and remove skin from poultry.
2.    Marinate before cooking.  By marinating and/or basting most foods prior to or during cooking we can cut way back on the AGEs created.  Use vinegar, citrus juice, herbs, spices, red wine and olive oil in your marinades because they have antioxidant properties
3.    Keep your grill clean; remove any build up of charred food
4.    Avoid charring food; remove any charred areas from food before eating
5.    Try poaching food on the grill.  Nothing is more delicious that salmon poached in an aluminum foil packet, whether in the oven or on the grill.

Wild salmon is in season and is an excellent barbecue choice.  It is also one of the world’s most “wine friendly” entrees, working well with crisp whites or more robust reds.  For optimum flavor and anti-oxidants, try Pinot Noir or a glass of iced green tea with this dish.

Salmon, Chicken or Tofu Kabobs with a Basting Marinade of Fresh Lime and Rosemary
Makes 4 servings

Ingredients

4 (6-oz. each) skinless-boneless wild salmon fillets, boneless, skinless chicken breasts, or bricks of firm tofu, cut into chunks
4 large white mushrooms
1 medium zucchini sliced
1 large red bell pepper seeded and quartered
1 large onion peeled and quartered
salt
freshly ground black pepper

12 skewers
Note: If using wooden skewers soak in water for at least an hour, so they don’t scorch on grill.

Garnishes
lime slices
rosemary sprigs

Basting sauce
1/3 cup chopped shallots
1/3 cup extra virgin olive oil
2 tablespoons Dijon mustard
3 tablespoons fresh lemon juice
2 tablespoons chopped fresh thyme
1 tablespoon grated lemon zest (use organic lemons to avoid the pesticide residues that accumulate in citrus rinds)
Freshly ground sea salt and black pepper to taste

Preparation
•    Wash mushrooms; remove and discard stems. Wash peppers and remove seeds.
•    Thread vegetables onto skewers. Cook on grill over medium heat for about 10 minutes, turning occasionally and basting with marinade.  Grilled veggie kabobs make the perfect accompaniment to our savory skewered salmon, chicken or tofu
•    Rinse the fish, chicken or tofu and pat dry. Cut into large cubes suitable for skewering.
•    Place the salmon cubes in a shallow baking dish and sprinkle with freshly grated    sea salt and pepper.
•    Place the marinade ingredients in a small bowl and whisk together until blended.
•    Pour the marinade over the fish and marinate for at least 10 minutes.
•    Lace the salmon, chicken or tofu onto the skewers and broil (or grill) for 5 minutes, turning once.
•    While the fish (et al) is cooking, pour the marinade in a small saucepan and heat it over medium heat.

To serve
Divide the fish among 4 serving plates and spoon some of the heated marinade over each. Garnish each plate with a few lime slices and a sprig of fresh rosemary and serve.

As an active researcher I welcome your comments and suggestions.

Nicholas Perricone, MD, FACN, CNS

The Science Behind Pigment Corrective

Pigment Corrective is a powerful treatment that helps to reverse the signs of hyper-pigmentation or brown spots resulting from sun damage or chronological age. By lightening and brightening the skin’s appearance, it imparts a more youthful, radiant complexion.

Independent clinical studies demonstrated extraordinary results:

• 100% reported a decrease in the appearance of new brown spots
• 96% reported their skin appeared brighter

How is it unique?
Pigment Corrective is safe and effective. Regular use improves the appearance of brown spots and hyper-pigmentation, while brightening the skin’s appearance with Pycnogenol® and Vitamin C Ester. It also helps tone skin, improves elasticity and smoothes the appearance of lines and wrinkles with DMAE.

The science
Pycnogenol® is sourced from maritime pine trees in the South of France, known for their centuries-old healing properties. It improves skin health and collagen renewal, while providing potent antioxidants to brighten skin.

Pigment Corrective complements any skincare regimen and can be used in combination with your favorite Perricone Products to help reduce the appearance of age spots. The topical cream is most effective when used with Pigment Corrective dietary supplements. Both of these will be made cheaper with Perricone coupons.

The Antioxidant, Anti-Inflammatory Power Of Olive Oil Polyphenols

Olive oil polyphenols are important antioxidants (natural anti-inflammatories) found in highest concentrations in extra virgin olive oil. They are essential to an anti-inflammatory diet.
One of the most important components of olive oil is hydroxytyrosol, an extremely rare, highly potent polyphenol. Hydroxytyrosol can actually slow the aging process in the skin by stabilizing the part of the cell known as the cell plasma membrane.
Researchers worldwide find that diets rich in olive oil polyphenols are associated with healthier breast tissue, colon function, and cardiovascular function, and offer significant extra protection from secondary smoke and sun-related skin damage.
Extra virgin olive oil is unique when it comes to foods that have a direct impact on beautiful skin and is a critical part of the Perricone Prescription Diet.
A few of the benefits of a diet rich in anti-inflammatory antioxidant extra virgin olive oil include:

• Increases the skins ability to maintain moisture;
• decreases “bad cholesterol”;
• increases “good cholesterol”;
• helps intestinal absorption;
• helps gall bladder activity;
• lowers probability of gallstones;
• lowers blood pressure;
• decreases gastric acid secretion in ulcers;
• stimulates pancreas secretion;
• aids developing bone in children;
• prevents osteoporosis;
• lowers glucose levels in diabetics;
• reduces risk of prostate cancer; and
• reduces the risk of breast cancer

Olive oil polyphenols offer additional benefits when incorporated into topical formulations, including the following:

• The delivery of the polyphenol anti-oxidant benefits directly to the skin
• Provides an all-natural approach to the prevention of free-radical damage
• Minimizes the appearance of lines and wrinkles while it brightens and evens skin tone.
• Extremely gentle and non-irritating; safe for even the most sensitive skin
• Guards against signs of premature aging

Ethnicity and Skin – Hispanic/Latino Skin Tone

If you have Hispanic or Latino skin tone, here’s what to expect on the risk/reward front:

Risks
Can be acne prone due to very active sebaceous glands
Although not as sensitive as black or brown skin, can suffer an exaggerated inflammatory response from chemicals, irritants or mild trauma
Can suffer from large pores

Rewards
Increased melanin production offers great sun protection
Can have skin clear of fine lines and wrinkles
Resists sagging and loss of tone