Tag Archives: prevention

Preserving Lean Muscle Mass

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As we age we gain body fat and lose muscle mass. Fortunately there are several key nutrients that help us preserve lean muscle mass, such as conjugated linoleic acid (CLA) and chromium.

Experts in the field of nutrition report that the general population of the United States is deficient in chromium–and it should come as no surprise that low levels of chromium are associated with type 2 diabetes and cardiovascular disease—both of which are endemic in developed countries.

In a placebo-controlled, cross-over study, Dr. Preuss and a team of researchers at Georgetown University Medical Center showed that overweight African-American women consuming 600 mcg of chromium as niacin-bound chromium trade name ChromeMate® for 8 weeks had a significant loss of body fat and sparing of muscle (lean body mass) compared with a prior placebo period of the same duration. Increased fat loss was also observed among women who were randomized to consume chromium first, followed by placebo, suggesting a carry-over effect of the supplementation on fat loss. No adverse effects were observed.

Studies have also been published noting that increased consumption of sugar (and related sweeteners) depletes our body stores of chromium, placing us at further risk for hyperglycemia and hyperinsulinemia (too much blood sugar, too much insulin).

In a perfect world, we would avoid refined sweeteners. Realistically we know that we all succumb to sugar’s siren song on occasion, therefore remember to make sure that you take a chromium supplement to prevent depleting your body’s stores of this important nutrient.

A Longer, Healthier Life, as easy as NBC

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For many years, researchers in the field of aging believed that the only way you could increase lifespan was by caloric restriction (CR). This is because low caloric intake will improve blood glucose levels and insulin sensitivity, thereby helping to prevent one of the most dangers pitfalls of aging, obesity, metabolic syndrome and diabetes. Recommend calorie deficits are approximately 250 – 500 calories, about 30% less food than we would normally eat. While this is an effective strategy, you won’t be incorrect when I state that is not overwhelmingly popular.

However, there is good news on the horizon. The nutritional supplement, niacin bound chromium (NBC) appears to produce similar effects when compared to caloric restriction.

Niacin Bound Chromium (NBC) for Life Extension
My colleague at Georgetown University’s School of Medicine, Dr. Harry Preuss, recently alerted me to very new and exciting findings. Animal studies found that chromium polynicotinate, also known as niacin-bound chromium (NBC) increased the average lifespan by twenty percent compared to animals taking a placebo. The NBC helps to lower the levels of circulating glucose (sugar) in the body. One of the reasons I advocate eliminating (as much as possible) sugar and simple starches from your diet is because high levels of circulating glucose in the body increase the presence of free radicals, which are the primary cause of metabolic disorders which can lead to diabetes. Scientists have repeatedly demonstrated that diabetes represents a premature form of aging, because of the damage caused by the excessively perturbed glucose-insulin system. This is really exciting news and one of the first strategies (other than caloric deprivation) shown to positively impact life-span

Chromium is a very important trace mineral that promotes normal insulin function and is essential for proper protein, fat and carbohydrate metabolism. As any anti-aging scientist well knows, elevated levels of insulin and blood sugar significantly accelerate cellular aging. Research now shows that the type of chromium known as NBC has a superior anti-aging and safety profile.

Extensive clinical and basic research utilizing a unique form of oxygen-coordinated niacin-bound chromium—generally known as chromium nicotinate or polynicotinate (trade name ChromeMate®) has shown that the niacin-bound form of chromium is the superior form (some forms have a worrisome profile, therefore I recommend utilizing the ChromeMate® brand for both safety and efficacy).

This form of NBC provides significant health benefits to those with diabetes and with metabolic syndrome and is, indeed, the most optimal form of chromium available as a dietary supplement.
The main benefits of NBC include:
• Promotion of proper insulin function and normal blood sugar levels
• Promotion of healthy blood cholesterol levels, normal blood pressure, and cardiovascular health
• Promotion of healthy body weight and lean body mass

Preserving Lean Muscle Mass
As we age we gain body fat and lose muscle mass. Fortunately there are several key nutrients that help us preserve lean muscle mass, such as conjugated linoleic acid (CLA) and chromium.

Experts in the field of nutrition report that the general population of the United States is deficient in chromium–and it should come as no surprise that low levels of chromium are associated with type 2 diabetes and cardiovascular disease—both of which are endemic in developed countries.

In a placebo-controlled, cross-over study, Dr. Preuss and a team of researchers at Georgetown University Medical Center showed that overweight African-American women consuming 600 mcg of chromium as niacin-bound chromium trade name ChromeMate® for 8 weeks had a significant loss of body fat and sparing of muscle (lean body mass) compared with a prior placebo period of the same duration. Increased fat loss was also observed among women who were randomized to consume chromium first, followed by placebo, suggesting a carry-over effect of the supplementation on fat loss. No adverse effects were observed.

Studies have also been published noting that increased consumption of sugar (and related sweeteners) depletes our body stores of chromium, placing us at further risk for hyperglycemia and hyperinsulinemia (too much blood sugar, too much insulin).

In a perfect world, we would avoid refined sweeteners. Realistically we know that we all succumb to sugar’s siren song on occasion, therefore remember to make sure that you take a chromium supplement to prevent depleting your body’s stores of this important nutrient.

As always I welcome your comments and suggestions,

Nicholas Perricone, MD, FACN, CNS

In Full Swing—Secrets to a Longer, Healthier Life

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Scientists long ago established that exercise greatly reduces both the incidence and severity of age-related degenerative diseases.  But we don’t just want to live longer; we want to extend the number of our healthy years.  We want to stay fit and active with the capacity to enjoy life to its fullest.  Gerontologists refer to this as our ‘health span’ – as opposed to our simple “life span” – and universally agree that exercise is a crucial component to extend and improve them both.  The right exercise will strengthen our bones and muscles, improve and restore physical and emotional balance, relieve stress and improve physical, mental and emotional health.

Exercise will also significantly decrease the effects of what is known as “secondary aging”- the occurrence and severity of diseases associated with aging.  In fact, it is these degenerative diseases from arthritis to Alzheimer’s that are often responsible for reducing both the life and the health span.  Exercise is a key element in helping us to prevent disease and prolong our good health into our seventh, eighth, ninth decade and beyond.  In recognition of this, I would like to tell you about a wonderful story headlined “102 Year-Old Golfer Scores Hole in One.”  Elsie McLean, a golfer since the 1920’s set a new world record for the oldest woman, or man to hit a hole in one.  “Well everybody wants a hole-in-one, and I said, ‘Why can’t I have a hole-in-one?’ I came within inches once,” Elsie told television station KNVN. She broke the age record of 101 set by Harold Stilson in 2001 at Deerfield Country Club in Florida. “For an old lady,” she said, “I still hit the ball pretty good.” She added.

Elsie not only enjoys a physically active lifestyle and fresh air through her love of golf, she also has friends to enjoy the game with—thereby avoiding two of the sorrows of advanced age, loneliness and isolation.

As always I welcome your comments and suggestions.

Nicholas Perricone, MD, FACN, CNS

Barbecue Your Way to Beautiful Skin

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It’s summertime, and the grilling is easy.

Once of the joys of summertime is the barbecue.  Nothing tastes better than food cooked outdoors over an open fire.  But cooking muscle meats and other protein foods at high heats can create carcinogenic chemicals called heterocyclic amines (HCAs).  In addition, Advanced Glycation End Products (AGEs) are also created.  The more AGEs we have, the more oxidative stress in our bodies, accelerating aging and disease risk in all organ systems, including skin.  In fact, AGEs play a key role in both healthy aging and preventing wrinkles and deeply lined, sagging skin.

We can still barbecue and reduce our risk of creating toxins if we follow a few simple rules.

1.    Choose lean meat, ideally from grass fed cattle or lamb, fish and free-range poultry; trim any excess fat from meat and remove skin from poultry.
2.    Marinate before cooking.  By marinating and/or basting most foods prior to or during cooking we can cut way back on the AGEs created.  Use vinegar, citrus juice, herbs, spices, red wine and olive oil in your marinades because they have antioxidant properties
3.    Keep your grill clean; remove any build up of charred food
4.    Avoid charring food; remove any charred areas from food before eating
5.    Try poaching food on the grill.  Nothing is more delicious that salmon poached in an aluminum foil packet, whether in the oven or on the grill.

Wild salmon is in season and is an excellent barbecue choice.  It is also one of the world’s most “wine friendly” entrees, working well with crisp whites or more robust reds.  For optimum flavor and anti-oxidants, try Pinot Noir or a glass of iced green tea with this dish.

Salmon, Chicken or Tofu Kabobs with a Basting Marinade of Fresh Lime and Rosemary
Makes 4 servings

Ingredients
4 (6-oz. each) skinless-boneless wild salmon fillets, boneless, skinless chicken breasts, or bricks of firm tofu, cut into chunks
4 large white mushrooms
1 medium zucchini sliced
1 large red bell pepper seeded and quartered
1 large onion peeled and quartered
salt
freshly ground black pepper

12 skewers
Note: If using wooden skewers soak in water for at least an hour, so they don’t scorch on grill.

Garnishes
lime slices
rosemary sprigs

Basting sauce
1/3 cup chopped shallots
1/3 cup extra virgin olive oil
2 tablespoons Dijon mustard
3 tablespoons fresh lemon juice
2 tablespoons chopped fresh thyme
1 tablespoon grated lemon zest (use organic lemons to avoid the pesticide residues that accumulate in citrus rinds)
Freshly ground sea salt and black pepper to taste

Preparation
•    Wash mushrooms; remove and discard stems. Wash peppers and remove seeds.
•    Thread vegetables onto skewers. Cook on grill over medium heat for about 10 minutes, turning occasionally and basting with marinade.  Grilled veggie kabobs make the perfect accompaniment to our savory skewered salmon, chicken or tofu
•    Rinse the fish, chicken or tofu and pat dry. Cut into large cubes suitable for skewering.
•    Place the salmon cubes in a shallow baking dish and sprinkle with freshly grated    sea salt and pepper.
•    Place the marinade ingredients in a small bowl and whisk together until blended.
•    Pour the marinade over the fish and marinate for at least 10 minutes.
•    Lace the salmon, chicken or tofu onto the skewers and broil (or grill) for 5 minutes, turning once.
•    While the fish (et al) is cooking, pour the marinade in a small saucepan and heat it over medium heat.

To serve
Divide the fish among 4 serving plates and spoon some of the heated marinade over each. Garnish each plate with a few lime slices and a sprig of fresh rosemary and serve.

As an active researcher I welcome your comments and suggestions.

Nicholas Perricone, MD, FACN, CNS

Maitake Mushrooms Benefits for Weight Loss and Immune System

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In the northeastern woods of Japan and the United States grows a ruffly-looking, exotic fungus with exciting possibilities, both culinary and nutritional. Called maitake or hen of the woods mushrooms, their woodsy aroma, meaty texture, and rich flavor have long given them special status in Japanese cuisine. Now, research is showing that maitake have potential that goes far beyond the kitchen.

Traditional Chinese medicine credited maitake and other mushrooms with having medicinal powers for centuries, but in the last 30 years Japanese researchers have examined the specific ways mushrooms act within the body to fight disease and improve health. The results have been encouraging. According to various studies, maitakes appear to boost the immune system, reduce blood sugar levels, aid in lowering blood pressure, encourage weight loss, and help to both prevent and fight cancer.

Most of maitake’s health benefits seem to come from one main source. They contain beta-glucan, a polysaccharide compound thought to help the immune system by activating effector cells like macrophages, natural killer cells, and T cells. In addition to their role in general immunity, these types of antibodies also act against cancer. The polysaccharide is also thought to be the source of the mushroom’s ability to control blood sugar to help manage diabetes and improve weight loss.

On top of all that, maitakes are also a rich source of minerals like potassium, calcium and magnesium, B vitamins, and amino acids. With all that and the fact that they taste great too, it’s more than worth checking out these exotic fungal gems.

For an even easier way to harness the power of maitake mushrooms for your health, also check out Perricone MD’s Maitake Mushroom Extract.

Cancer in Women: New Paths For Early Detection

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Cures for breast, cervical, and ovarian cancers are still years away, but seemingly every day there is more exciting news about the power of prevention and early detection.  A better understanding of the root causes of these cancers along with an increased focus on healthy lifestyle practices and sophisticated screenings continues to give women power over the diseases.

For example ovarian cancer already has a 92% survival rate if diagnosed in the early stages. However, it surpasses even breast cancer as the leading cause of death from gynecological malignancies. Its early symptoms are nonspecific ones including abdominal pain, bloating, and tiredness. This lack of urgent symptoms means  that more than 2/3 of women aren’t diagnosed until the later stages when the survival rate drops to 20-30 percent. A study of 200,000 woman in the United Kingdom hopes to prove that the combination of a blood test for levels of a protein called CA125 along with an ultrasound will make it easier to find early ovarian cancer and result in fewer false positive tests.

In the 1950s, cervical cancer was the leading cause of cancer death among women. Widespread use of the Pap test means that currently, fewer than 4,000 American women a year die from it. However, the disease is still devastating in less developed nations. A better understanding of the role that human papilloma virus plays in causing cervical cancer could change that. A new DNA test that detects HPV is leading to cheaper, faster, more accurate, and easier to read tests that should help reduce those numbers all over the world.

Finally, as if lowering your risk for heart disease, high blood pressure, and high cholesterol weren’t reasons to get more exercise, there’s a strong link between increased physical activity and a decreased likelihood of death from breast cancer. A study of 14,000 women showed that those with a high level of fitness were a full three times less likely to die from breast cancer than those with a lower level of fitness.

Gynecological cancers that were once silent killers that struck from nowhere and showed no symptoms until they were dangerously advanced are more conquerable than ever. When it comes to living a long, healthy, cancer-free life, it seems that an ounce of prevention, plus a healthy dose of sophisticated detection, is nearly as valuable as a cure.