Yesterday, I highlighted the importance of ‘Master Antioxidant’ glutathione, (pronounced “gloo-tuh thigh-own”). Scientists and physicians, myself included, have spent many years researching methods to increase glutathione within the mitochondria. Elevating glutathione levels and other substances that protect against free-radical damage in the mitochondria is the cornerstone of our quest to look and feel forever young.
One of the greatest challenges in working with glutathione is the fact that glutathione supplementation has not been viable. This is because oral ingestion of supplemental glutathione is rapidly digested by the gastrointestinal system. Fortunately, we are finding ways to circumvent this problem. One such method is the focal point of my own research: the development of a phospholipid carrier system that is capable of transferring glutathione into the cells. This transdermal delivery system allows the mitochondria to receive increased levels of this protective tripeptide. When applied to the skin, glutathione, via the phospholipid carrier, is able to penetrate various levels, reaching into the deep dermis and finally into the subdermal microvasculature, or the small blood vessels under the skin. From this point, glutathione begins circulating into our blood, providing protective glutathione molecules to all organ systems and cells. When delivered in this form, the glutathione is able to enter the cells and provide elevated levels for increased protection. Once in the cell, the higher levels of glutathione are available to the mitochondria, where they help to maintain health and prevent disease.
How do you maintain glutathione levels?
Dear Dr. Perricone,
I am a Asian people, aged only twenty-three years old, I’m male. I have sensitive skin, has been used as a basis Avene skin care. Perricone now want to use this product, which series is more suitable, I can not find the answer, can help me. Really thank you.
Hi Anday. What sort of skin concerns do you have?
Helo, I have been using the Serum-prep, Cold Plasma, Intensive Moisturizer. Bought the Acyl- Gluthatione, I asked how to use it, and I was told to wear it on top of all the other treatment, last night I put it on and and had a red rash in either side of my nose and chin cleaned my face and just used the first 3, I am 58, have very sensitive skin. Please give me some direction let me know how and when is the Acyl-Gluthatione is appropiate to use. Thank you
Hi Laura. Sorry to hear about your reaction. It is correct to apply the Acyl on top of your other products. It sounds like that combination could be too much for you. Please patch test the Acyl to ensure no allergic reaction on your neck. Then, you can try applying just the acyl on your face at nights to see how your skin behaves. Once you are able to tolerate just the Acyl on cleansed and prepped skin at nights, add the Cold Plasma back in, prior to your Acyl. Please keep us posted Laura!
Doctor Perricone:
Why do you call this formulation “acyl-glutathione”? Are you transferring an acyl group at some point in the process?
Hi Frank. It’s called Acyl-Glutathione because of the form used in the product.