The interior of the cell is filed with a gelatinous material that houses the nucleus, DNA, and protein “transcription factors.” These proteins are nothing more than tiny molecular messengers that can move to the nucleus to stimulate our DNA to replicate RNA and make important proteins for cell function.
Here we want to concentrate on two important transcription factors, nuclear factor kappa B (NF-kB) and activator protein 1 (AP-1). These transcription factors are not active in the cell unless the redox level of the cell changes and free radicals are about to overwhelm the cell’s defense mechanism, a state called oxidative stress. When the cells undergo oxidative stress, the transcription factors are activated. NF-kB migrates to the nucleus and attaches to the DNA, resulting in the cellular production of pro-inflammatory cytokines – chemicals that are the so-called “serial killers” of the cellular world. AP-1 migrates to the nucleus where it causes the production of a variety of chemicals, including collagenases, which digest collagen. Our beautiful, youthful skin, chiefly composed of collagen, has no defense against these collagen-digesting enzymes.
When collagen is digested, it results in the micro-scars that lead to wrinkles.
As an active researcher, I welcome your comments and suggestions.
I have worked extensivley in the health and beauty industry for more than 20 years. The research and information provided by Dr Perricone over many years has changed everything about the way I work, look after my skin and the way I eat! The role played by systemic inflamation cannot be ignored….it’s staring us in the face!!!!
Lorraine
I love some of the simple advise you give like an apple a day keeps the Dr. away. I have been eating more apples lately and noticed that they do act as an appitite suppresant.
Thanks for the advise.
Hi Dr Perricone,
I have been taking Doxycycline for years to control my acne on my face. I did research on doxycycline before taking this antibiotic and read that it inhibits the production of collagenases, also known as MMP-1. Is this correct? And by taking this medication is it preventing wrinkles from occuring?
Interesting facts!
No wrinkles, stay out of the sun. BUT, I am jowley, I can pack away nuts for the winter. What now, not a fan of surgery.
Thanks. PS am 61 yrs old.
As a nurse, I am in awe of how amazingly we were created and love learning more about how our bodies work. Thanks for posting the cellular biology aspects of aging! Also, as a 43 year old mom to a 1 year old and a 3 year old, I am determined to take the best care of myself possible, so I will be around and have more than enough energy to play with my grandkids oneday. Plus, I also want my kids friends to say one day “your mom is HOW OLD?! No way!”
I love learning about all this..please keep posting it for us!
Thank you for being so dedicated to your work and your science; the results are spectacular!
I have been using your products for a few years and I would never be without! Your advice on nutrition is always wise and very welcome! Even my husband thanks you because he notices the difference.
Thank you for all the info. I am 72 years old and very active living in Fl. What is the best product I can use on my skin even though I am on a budget. Thanks you.