The Top 10 Weight Loss Supplements


The Perricone Anti-Inflammatory Weight Loss Diet nutrients work in a special way to enhance loss of body fat, preserve muscle mass and regulate levels of blood sugar and insulin. They will also promote beautiful, healthy, youthful-looking skin.

  1. Alpha Lipoic Acid (ALA)
    Alpha lipoic acid, often referred to as ‘the universal antioxidant,” is a potent antioxidant and anti-inflammatory found naturally inside of the energy producing portion of the cell known as the mitochondria. Alpha lipoic acid enhances our ability to metabolize food into energy. ALA is a unique antioxidant because it is both fat and water soluble. This means it can go to all parts of the cell, including the lipid (fat) portions such as the cell plasma membrane, as well as the interior of the cell (known as the cytoplasm) where water soluble chemicals reside.
  2. DMAE (dimethylaminoethanol)
    DMAE is a naturally occurring nutritional substance with powerful anti-inflammatory properties; it is found in fish including wild Alaskan salmon, anchovies and sardines. DMAE is important in the production of neurotransmitters, which are essential in the communication from one nerve to another and between nerves and muscles. Taking DMAE as a supplement will not only improve your cognitive function by improving memory and problem-solving ability, it will help increase skin firmness and muscle tone—important for anyone on a weight loss or antiaging program.
  3. Glutamine
    Glutamine is the body’s most abundant amino acid. It plays an important role in keeping the muscles functioning properly and helps reduce muscle deterioration. Glutamine literally drives muscle-building nitrogen into the muscle cell where it is synthesized for growth. It is also converted into glucose when the body needs more energy. When the body is in a highly inflammatory state, it breaks down our muscle tissue to get the extra glutamine needed, resulting in muscle mass loss.
  4. Carnitine
    Carnitine and its derivative, acetyl L-carnitine, are two of the most important nutrients for weight loss. Carnitine is critical for energy formation and an active metabolism. Carnitine transports the fatty acids from our blood into the cell for this energy production. Thus, for carnitine to have optimum effect, we must have adequate essential fatty acids, such as omega 3’s, present in the diet.
  5. Acetyl L-carnitine
    Acetyl L-carnitine acts as an antioxidant, a natural anti-inflammatory that enhances the affects of the other antioxidant systems within the body. These anti-inflammatory properties protect the cell plasma membrane (the cell’s first line of defense) and prevent the conversion of arachidonic acid into pro-inflammatory chemicals. Although exercise will naturally increase our levels of acetyl L-carnitine, if we are obese, over thirty or have other health problems, it will not raise them to therapeutic levels, therefore supplementation is necessary.
  6. Coenzyme Q – 10
    Coenzyme Q-10, also called ubiquinone, is a powerful antioxidant/anti-inflammatory with many benefits for treating and preventing obesity. It acts similarly to acetyl L-carnitine in that it assists in energy production within the mitochondria. CoQ10 enhances the metabolism, giving us greater energy and endurance, a greater ability to lose body fat, preventing the energy decline seen in aging cells. CoQ10 also maximizes the burning of foods for fuel, helping to normalize fats in our blood.
  7. Conjugated Linoleic Acid (CLA)
    Conjugated linoleic acid is a fatty acid found in many of the foods we eat. At one time, beef and lamb were exceptional sources; however when their diet was changed from grass to grain, levels of CLA dramatically decreased in the meat and dairy products. CLA has powerful antioxidant/anti-inflammatory activity. It decreases body fat, especially in the area of the abdomen and helps block the absorption of fat and sugar into fat cells (adipocytes). It also helps the insulin receptors remain intact, thus increasing insulin sensitivity.
  8. Chromium
    Because Chromium is an essential nutrient for normal sugar and fat metabolism, it is critical in our effort to control and reduce excess body fat. Chromium supplementation effectively lowers blood sugar and insulin levels and can also increase levels of the ‘good’ HDL cholesterol. This lowers total cholesterol and triglycerides, thus playing a key role in regulating appetite, reducing sugar cravings, and lowering body fat.
  9. Gamma Linolenic Acid (GLA)
    Gamma linolenic acid is an important omega-6 essential fatty acid. The average American diet causes a deficiency of GLA because of the large amounts of trans fatty acids, sugar, red meats and dairy products. The body rapidly converts GLA into dihomo-gamma-linoleic acid, the precursor of prostaglandin E1, a powerful anti-inflammatory hormone-like compound that helps to regulate inflammation, blood pressure, and many other bodily processes.
  10. Maitake Mushroom Extract
    Studies show that maitake mushroom extract enhances insulin sensitivity for controlling blood sugar levels and may serve as a safe and reliable weight loss supplement—even without additional behavior modifications, such as decreased caloric intake and increased exercise. It is established as a powerful tool in preventing a dangerous quartet of metabolic imbalances that increase our risk of cardiovascular disease and diabetes called Metabolic Syndrome. Metabolic Syndrome consists of high blood pressure, elevated levels of insulin, excess weight (especially around the abdomen), and dyslipidemialow, or low levels of HDL (good) cholesterol, high levels of LDL (bad) cholesterol, and high levels of triglycerides. Read more about Maitake Mushroom benefits.

19 thoughts on “The Top 10 Weight Loss Supplements

  1. Am very anxoius to begin the three day face lift program and go from there. My
    friend who recommended your site has lost weight and firmed up lose skin on your program. Please enter me in your contest for the Amine Complex Face lift

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  3. Donna says she has been taking all of the supplements? I am just curious about how to take the supplements. Take the suggested does of each everyday? Or how do you chose which to take and when to take them?

    • Hi Jennifer. To spare you the guess work, Dr. Perricone has created comprehensive supplement regimens for different concerns. If weight loss is your primary concern, we recommend starting with the Metabolic Formula, then transitioning to Heath and Weight Management or Skin and Total Body. For more information, please visit:

    • You can buy the supplements online individually through a number of vitamin/supplement websites and then search Perricone’s website for the recommended dosage, etc. I did it this way and it ended up being less expensive than buying the Metabolic Formula.

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  6. Having read this I thought it was rather informative.
    I appreciate you spending some time and effort to put this
    informative article together. I once again find myself spending way too much time both reading
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  7. However, you’ll find much healthier techniques for getting a little protein.
    You’ll get no arguments from me to go over a diet this good.
    If you miss your session by an hour or so, it is pretty much not doing it anyway.
    If you combine 25 to 45 minutes of exercise at least three times every week your metabolism
    will stay active and you will probably burn off extra calories.
    Well which was the prevailing thought, however, the final results were not even close to successful, with only minimal weight
    being lost.


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